A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.

ABSTRACT: Diverse interneuron subtypes shape sensory processing in mature cortical circuits. During development, sensory deprivation evokes powerful synaptic plasticity that alters circuitry, but how different inhibitory subtypes modulate circuit dynamics in response to this plasticity remains unclear. We investigate how deprivation-induced synaptic changes affect excitatory and inhibitory firing rates in a microcircuit model of the sensory cortex with multiple interneuron subtypes. We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together. To explain the experimentally observed independent modulation, whereby one firing rate increases and the other decreases, requires strong feedback f

SUBMITTER: Richter LMA 

PROVIDER: S-EPMC9371725 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature