Nonconcomitant host-to-host transmission of multipartite virus genome segments may lead to complete genome reconstitution.

ABSTRACT: Because multipartite viruses package their genome segments in different viral particles, they face a potentially huge cost if the entire genomic information, i.e., all genome segments, needs to be present concomitantly for the infection to function. Previous work with the octapartite faba bean necrotic stunt virus (FBNSV; family Nanoviridae, genus Nanovirus) showed that this issue can be resolved at the within-host level through a supracellular functioning; all viral segments do not need to be present within the same host cell but may complement each other through intercellular trafficking of their products (protein or messenger RNA [mRNA]). Here, we report on whether FBNSV can as well decrease the genomic integrity cost during between-host transmission. Using viable infectio

SUBMITTER: Di Mattia J 

PROVIDER: S-EPMC9371732 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature