Tumor-polarized GPX3⁺ AT2 lung epithelial cells promote premetastatic niche formation.

ABSTRACT: The cellular and molecular components required for the formation of premetastatic niche (PMN) to promote lung metastasis need to be further investigated. Lung epithelial cells have been reported to exhibit immunomodulatory roles in lung homeostasis and also to mediate immunosuppressive PMN formation in lung metastasis. Here, by single-cell sequencing, we identified a tumor-polarized subpopulation of alveolar type 2 (AT2) epithelial cells with increased expression of glutathione peroxidase 3 (GPX3) and high production of interleukin (IL)-10 in the PMN. IL-10-producing GPX3⁺ AT2 cells inhibited CD4⁺ T cell proliferation but enhanced regulatory T cell generation. Mechanistically, tumor exosome-inducing GPX3 expression is required for GPX3⁺ AT2 cells to prefere

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9371733 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature