Previous SARS-CoV-2 infection or a third dose of vaccine elicited cross-variant neutralising antibodies in vaccinated solid-organ transplant recipients.

ABSTRACT:

Objectives

The SARS-CoV-2 pandemic poses a great threat to global health, particularly in solid organ transplant recipients (SOTRs). A 3-dose mRNA vaccination protocol has been implemented for the majority of SOTRs, yet their immune responses are less effective compared to healthy controls (HCs).

Methods

We analyzed the humoral immune responses against the vaccine strain and variants of concern (VOC), including the highly mutated-omicron variant in 113 SOTRs, of whom 44 had recovered from COVID-19 (recovered-SOTRs) and 69 had not contracted the virus (COVID-naïve). In addition, 30 HCs, 8 of whom had recovered from COVID-19, were also studied.

Results

Here, we report that three doses of the mRNA vaccine had only a modest effect in eliciting anti-viral antibodies agains

SUBMITTER: Chang CC 

PROVIDER: S-EPMC9371857 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature