Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats.

ABSTRACT: Loss of cognitive function is a typical consequence of aging in humans and rodents. The extent of decline in spatial memory performance of rats, assessed by a hole-board test, reaches from unimpaired and comparable to young individuals to severely memory impaired. Recently, proteomics identified peroxiredoxin 6, an enzyme important for detoxification of oxidized phospholipids, as one of several synaptosomal proteins discriminating between aged impaired and aged unimpaired rats. In this study, we investigated several components of the epilipidome (modifications of phospholipids) of the prefrontal cortex of young, aged memory impaired (AI) and aged unimpaired (AU) rats. We observed an age-related increase in phospholipid hydroperoxides and products of phospholipid peroxidation, including rea

SUBMITTER: Narzt MS 

PROVIDER: S-EPMC9372013 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature