The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates.

ABSTRACT: Substance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive function. We tested whether a common genetic factor undergirds liability to problematic alcohol use (PAU), problematic tobacco use (PTU), cannabis use disorder (CUD), and opioid use disorder (OUD) by applying genomic structural equation modeling to genome-wide association study summary statistics for individuals of European ancestry (Total N = 1,019,521; substance-specific Ns range: 82,707-435,563) while adjusting for the genetics of substance use (Ns = 184,765-632,802). We also tested whether shared liability across SUDs is associated with behavioral constructs (risk-taking, executive function, neurotic

SUBMITTER: Hatoum AS 

PROVIDER: S-EPMC9372072 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature