Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.

ABSTRACT: Innate lymphoid cells (ILCs) exert important roles in host defense, tissue repair and inflammatory diseases. However, how ILC lineage specification is regulated remains largely elusive. Here we identify that circular RNA circTmem241 is highly expressed in group III innate lymphoid cells (ILC3s) and their progenitor cells. CircTmem241 deficiency impairs ILC3 commitment and attenuates anti-bacterial immunity. Mechanistically, circTmem241 interacts with Nono protein to recruit histone methyltransferase Ash1l onto Elk3 promoter in ILC progenitor cells (ILCPs). Ash1l-mediated histone modifications on Elk3 promoter enhance chromatin accessibility to initiate Elk3 transcription. Of note, circTmem241^-/-, Nono^-/- and Ash1l^-/- ILCPs display impaired ILC3 differentiat

SUBMITTER: Liu N 

PROVIDER: S-EPMC9372085 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature