Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function.

ABSTRACT: Major depressive disorder (MDD) and opioid use disorder (OUD) are common, potentially fatal, polygenic disorders that are moderately heritable and often co-occur. We examined the unique and shared associations of polygenic risk scores (PRS) for these disorders with µ-opioid receptor (MOR) concentration and endogenous opioid response during a stressful stimulus. Participants were 144 healthy European-ancestry (EA) subjects (88 females) who underwent MOR quantification scans with [¹¹C]carfentanil and PET and provided DNA for genotyping. MOR non-displaceable binding potential (BP_ND) was measured in 5 regions of interest (ROIs) related to mood and addiction. We examined associations of PRS both at baseline and following opioid release calculated as the ratio of baseline a

SUBMITTER: Love T 

PROVIDER: S-EPMC9372136 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature