Genomic analysis of hypervirulent Klebsiella pneumoniae reveals potential genetic markers for differentiation from classical strains.

ABSTRACT: The majority of Klebsiella pneumoniae (Kp) infections are nosocomial, but a growing number of community-acquired infections are caused by hypervirulent strains (hvKp) characterised by liver invasion and rapid metastasis. Unlike nosocomial Kp infections, hvKp are generally susceptible to antibiotics. Due to the rapid progression of hvKp infections, timely and accurate diagnosis is required for effective treatment. To identify potential drivers of the hypervirulent phenotype, we performed a genome-wide association study (GWAS) analysis on single nucleotide variants and accessory genome loci across 79 publicly available Kp isolates collected from patients' liver and a diverse global Kp dataset (n = 646). The GWAS analysis revealed 29 putative genes (P < 10^-10) associated with highe

SUBMITTER: Spadar A 

PROVIDER: S-EPMC9372168 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature