Digital reconstruction of infraslow activity in human intracranial ictal recordings using a deconvolution-based inverse filter.

ABSTRACT: Infraslow activity (ISA) is a biomarker that has recently become of interest in the characterization of seizure recordings. Recent data from a small number of studies have suggested that the epileptogenic zone may be identified by the presence of ISA. Investigation of low frequency activity in clinical seizure recordings, however, has been hampered by technical limitations. EEG systems necessarily include a high-pass filter early in the measurement chain to remove large artifactual drifts that can saturate recording elements such as the amplifier. This filter, unfortunately, attenuates legitimately seizure-related low frequencies, making ISA difficult to study in clinical EEG recordings. In this study, we present a deconvolution-based digital inverse filter that allows recovery of attenuat

SUBMITTER: Lee S 

PROVIDER: S-EPMC9372169 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature