CircHIPK2 promotes proliferation of nasopharyngeal carcinoma by down-regulating HIPK2.

ABSTRACT:

Background

Circular RNAs (circRNAs) are a new family of endogenous non-coding RNAs generated by a covalently closed loop, and a mounting body of data suggests they control gene expression. While the circRNA-homeodomain-interacting protein kinase-2 (circHIPK2) is generated from the homeodomain-interacting protein kinase 2 (HIPK2) gene, the function of circHIPK2 in nasopharyngeal cancer (NPC) along with the responsible mechanisms are still unclear.

Methods

RNA-sequencing data was utilized to determine the differentially expressed circRNAs, and circHIPK2 was established as a novel prospective circRNA. The expressions of circRNAs along with messenger RNAs (mRNAs) in NPC tissues and cells was assessed via quantitative real-time polymerase chain

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9372202 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature