Association between eight hypermethylation-related genes and gastric cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Although multiple gene promoter hypermethylation has been associated with gastric carcinogenesis, data on their specific relationship remains scant. We aimed to investigate the correlation between the status of multiple gene promoter methylation and gastric cancer (GC).

Methods

We searched PubMed, EMBASE, CNKI, Wanfang, Cqvip and Cochrane Library up to May 2021. We systematically assessed the association between methylation status of the CpG islands and the risk of GC. We compared the incidence of DNA methylation between tumor and non-tumor tissues, and evaluated the clinicopathological significance of the DNA methylation in gastric carcinoma. The data was presented by an odds ratio (OR) with an accompanying 95% confidence interval (CI). We then generated forest p

SUBMITTER: Ma C 

PROVIDER: S-EPMC9372225 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature