Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score.

ABSTRACT:

Background

Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets.

Methods

In total, 299 SNPs previously associated with prostate cancer were evaluated for inclusion in a new PHS, using a LASSO-regularized Cox proportional hazards model in a training dataset of 72,181 men from the PRACTICAL Consortium. The PHS model was evaluated in four testing datasets: African ancestry, Asian ancestry, and two of European Ancestry-th

SUBMITTER: Huynh-Le MP 

PROVIDER: S-EPMC9372232 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature