Stemness-related gene signature for predicting therapeutic response in patients with esophageal cancer.

ABSTRACT:

Background

Extensive research has indicated that tumor stemness promotes tumor progression. However, the underlying role of stemness-related genes (SRGs) in esophageal cancer (ESCA) remains unclear.

Methods

This study identified differentially expressed stemness-related (DESR) messenger RNAs (mRNAs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) in ESCA, and correlated them with the clinical features of patients with ESCA to develop a prognostic risk assessment model. Functional analysis, protein-protein interaction (PPI) analysis, competing endogenous RNA (ceRNA) networks, and tumor-infiltrating immune cell analyses were performed to corroborate the results obtained from the model.

Results

Correlation analysis of the stemness enrichment scores revealed 1,106

SUBMITTER: Zhu S 

PROVIDER: S-EPMC9372233 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature