Autophagy related DNA methylation signature predict clinical prognosis and immune microenvironment in low-grade glioma.

ABSTRACT:

Background

Low-grade glioma (LGG) is a common malignant tumor of the central nervous system. The clinical prognosis of different patients varies greatly, so exploring appropriate markers that affect the prognosis and treatment of LGG is important. The purpose of this study was to identify the potential effect of autophagy-related DNA methylation on the prognosis and immune microenvironment in LGG.

Methods

The methylation profile, transcription data and corresponding clinical information of 451 patients with LGG were obtained from The Cancer Genome Atlas (TCGA). Another methylation data and clinical information of 110 patients with LGG from Chinese Glioma Genome Atlas (CGGA) were used as the validation set. Through univariate and multivariate COX regression analysis, we ident

SUBMITTER: Qiao Q 

PROVIDER: S-EPMC9372237 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature