Sepsis affects kidney graft function and one-year mortality of the recipients in contrast with systemic inflammatory response.

ABSTRACT:

Background

Infections remain a major cause of morbidity and mortality after kidney transplantation. The aim of our study was to determine the effect of sepsis on kidney graft function and recipient mortality.

Methods

A prospective, observational, single-center study was performed. Selected clinical and biochemical parameters were recorded and compared between an experimental group (with sepsis, n = 34) and a control group (with systemic inflammatory response syndrome, n = 31) comprising kidney allograft recipients.

Results

Sepsis worsened both patient (HR = 14.77, p = 0.007) and graft survival (HR = 15.07, p = 0.007). Overall one-year mortality was associated with age (HR = 1.08, p = 0.048), APACHE II score (HR = 1.13, p = 0.0

SUBMITTER: Protus M 

PROVIDER: S-EPMC9372308 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature