Cerebral small vessel disease and perihematomal edema formation in spontaneous intracerebral hemorrhage.

ABSTRACT:

Objective

Blood-brain barrier (BBB) dysfunction is implicated in the pathophysiology of cerebral small vessel disease (cSVD)-related intracerebral hemorrhage (ICH). The formation of perihematomal edema (PHE) is presumed to reflect acute BBB permeability following ICH. We aimed to assess the association between cSVD burden and PHE formation in patients with spontaneous ICH.

Methods

We selected patients with spontaneous ICH who underwent 3T MRI imaging within 21 days after symptom onset from a prospective observational multicenter cohort study. We rated markers of cSVD (white matter hyperintensities, enlarged perivascular spaces, lacunes and cerebral microbleeds) and calculated the composite score as a measure of the total cSVD burden. Perihematomal edema formation was measure

SUBMITTER: Cliteur MP 

PROVIDER: S-EPMC9372363 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature