Histopathological modeling of status epilepticus-induced brain damage based on in vivo diffusion tensor imaging in rats.

ABSTRACT: Non-invasive magnetic resonance imaging (MRI) methods have proved useful in the diagnosis and prognosis of neurodegenerative diseases. However, the interpretation of imaging outcomes in terms of tissue pathology is still challenging. This study goes beyond the current interpretation of in vivo diffusion tensor imaging (DTI) by constructing multivariate models of quantitative tissue microstructure in status epilepticus (SE)-induced brain damage. We performed in vivo DTI and histology in rats at 79 days after SE and control animals. The analyses focused on the corpus callosum, hippocampal subfield CA3b, and layers V and VI of the parietal cortex. Comparison between control and SE rats indicated that a combination of microstructural tissue changes occurring after SE, such as cel

SUBMITTER: San Martin Molina I 

PROVIDER: S-EPMC9372371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature