Reduced tear thrombospondin-1/matrix metalloproteinase-9 ratio can aid in detecting Sjogren's syndrome etiology in patients with dry eye.

ABSTRACT: Differentiating patients with Sjögren's syndrome (SS)-associated dry eye from non-SS dry eye is critical for monitoring and appropriate management of possible sight- or life-threatening extraglandular complications associated with SS. We tested whether reduced tear levels of immunoregulatory thrombospondin (TSP)-1, which also inhibits matrix metalloproteinase (MMP)-9, would reflect SS pathogenesis aiding the identification of patients with SS-dry eye. Total of 61 participants, including healthy controls (n = 20), patients with non-SS dry eye (n = 20) and SS-dry eye (n = 21) were enrolled prospectively. Tear TSP-1 and MMP-9 levels were measured using a custom magnetic bead-based multi-plex assay in a masked manner. Analyte concentrations were assessed further according to ocular surface and

SUBMITTER: Masli S 

PROVIDER: S-EPMC9372415 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature