The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma.

ABSTRACT: The structural changes of airway smooth muscle (ASM) that characterize airway remodeling (AR) are crucial to the pathogenesis of asthma. During AR, ASM cells dedifferentiate from a quiescent to a proliferative, migratory, and secretory phenotype. Calcium (Ca²⁺) is a ubiquitous second messenger that regulates many cellular processes, including proliferation, migration, contraction, and metabolism. Furthermore, mitochondria have emerged as major Ca²⁺ signaling organelles that buffer Ca²⁺ through uptake by the mitochondrial Ca²⁺ uniporter and extrude it through the Na⁺/Ca²⁺ exchanger (NCLX/Slc8b1). Here, we show using mitochondrial Ca²⁺-sensitive dyes that NCLX only partially contributes to mitochondrial Ca²⁺

SUBMITTER: Johnson MT 

PROVIDER: S-EPMC9372629 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature