Gefitinib-induced hemorrhagic cystitis and inflammatory contracted bladder in a patient with advanced lung adenocarcinoma harboring compound epidermal growth factor receptor G719S and S768I missense mutations: a case report.

ABSTRACT:

Background

Numerous clinical studies have established the efficacy and safety of gefitinib for treating patients with epidermal growth factor receptor (EGFR)-mutant lung cancer. Gefitinib-induced urinary system-related adverse reactions are rare but may lead to discontinuation of gefitinib.

Case description

In our report, we describe a patient with advanced lung adenocarcinoma harboring compound EGFR G719S and S768I who developed hemorrhagic cystitis and inflammatory contracted bladder during first-line gefitinib therapy. A 56-year-old male smoker, presented with chronic cough, sputum expectoration, and shortness of breath for 6 months that had worsened over the last 2 weeks, was diagnosed with T2N2M1A stage IV adenocarcinoma of the right lower lung with bilate

SUBMITTER: Bai X 

PROVIDER: S-EPMC9372651 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature