Differential expression of microRNA in the serum of patients with polycystic ovary syndrome with insulin resistance.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disease in women of childbearing age, and insulin resistance is an important etiological mechanism in PCOS. This study revealed the microRNA (miRNA) expression profile of PCOS with insulin resistance and explored the potential biological functions of differentially expressed miRNA.

Methods

A total of 76 patients with PCOS and 30 normal healthy women were recruited in the gynecological clinic of the Second Hospital of Tianjin Medical University. We divided the patients with PCOS into a group with insulin resistance (n=46) and a group without insulin resistance (n=30). Peripheral venous serum samples from each group were used for deep sequencing to identify differentially expressed miRNAs. Hi

SUBMITTER: Huo Y 

PROVIDER: S-EPMC9372667 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature