Soluble ST2 in serum predicts the prognosis of idiopathic pulmonary fibrosis: a retrospective study.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a heterogeneous and progressive fibrosing interstitial lung disease with a poor prognosis. However, there are currently no effective biomarker that can reliably predict the prognosis for IPF in clinic. The serum level of soluble suppression of tumorigenicity-2 (sST2), which is involved in the immune response, has proven to be a prognostic predictor for various diseases. Previous studies have confirmed that the immune dysfunction plays an important role in the pathogenesis of IPF and the serum sST2 concentrations in patients with IPF are elevated. However, the relationship between sST2 and the prognosis of IPF remains unknown.

Methods

A total of 83 patients with IPF and 20 healthy controls from 2016 to 2021 were enrolled and d

SUBMITTER: Yu YZ 

PROVIDER: S-EPMC9372699 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature