Bioinformatic analysis of the role of solute carrier-glutamine transporters in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is a highly heterogeneous disease. Solute carriers (SLCs) have been involved in the tumor progression of various cancer types. This study aimed to evaluate the role of these SLC-related glutamine transporters in the prognosis of BC patients by bioinformatics analysis.

Methods

This study examined the transcription and prognostic data for glutamine-related transporters in BC from Oncomine Database, which is currently the largest oncogene microarray database platform in the world. As well as Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier (K-M), and cBioPortal online resources. The Tumor Immune Estimation Resource (TIMER) and GEPIA were also used to examine the relationship between SLCs and immune cell infiltration.

Results<

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9372701 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature