New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system.

ABSTRACT: The functions of a wide variety of molecules with structures similar to the classical class I and class II molecules encoded by the major histocompatibility complex (MHC) have been studied by biochemical and structural studies over decades, with many aspects for humans and mice now enshrined in textbooks as dogma. However, there is much variation of the MHC and MHC molecules among the other jawed vertebrates, understood in the most detail for the domestic chicken. Among the many unexpected features in chickens is the co-evolution between polymorphic TAP and tapasin genes with a dominantly-expressed class I gene based on a different genomic arrangement compared to typical mammals. Another important discovery was the hierarchy of class I alleles for a suite of properties including size of pe

SUBMITTER: Halabi S 

PROVIDER: S-EPMC9372762 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature