Functional neurodevelopment of working memory in early-onset schizophrenia: A longitudinal FMRI study.

ABSTRACT: Schizophrenia, a debilitating disorder with typical manifestation of clinical symptoms in early adulthood, is characterized by cognitive impairments in executive processes such as in working memory (WM). However, there is a rare case of individuals with early-onset schizophrenia (EOS) starting before their 18th birthday, while WM and its neural substrates are still undergoing maturation. Using the WM n-back task with functional magnetic resonance imaging, we assessed the functional neurodevelopment of WM in adolescents with EOS and age- and gender-matched typically developing controls. Participants underwent neuroimaging in the same scanner twice, once at age 17 and at 21 (mean interscan interval = 4.3 years). General linear model analysis was performed to explore WM neurodevelopmental cha

SUBMITTER: Ioakeimidis V 

PROVIDER: S-EPMC9372770 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature