Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities.

ABSTRACT: The management of hepatocellular carcinoma (HCC) is challenging because most patients have underlying cirrhosis, and the treatment provides, historically, a limited impact on the natural history of patients with advanced-stage disease. Additionally, recurrence rates are high for those patients who receive local and locoregional modalities, such as surgical (resection and transplantation) or image-guided (ablation and intra-arterial) therapies. Translational research has led to new concepts that are reshaping the current clinical practice. Substantial advancements were achieved in the understanding of the hallmarks that drive hepatocarcinogenesis. This has primed a successful incorporation of novel agents with different targets, such as anti-angiogenic drugs, targeted-therapies, and immune-

SUBMITTER: da Fonseca LG 

PROVIDER: S-EPMC9372805 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature