Comprehensive proteomic signature and identification of CDKN2A as a promising prognostic biomarker and therapeutic target of colorectal cancer.

ABSTRACT:

Background

The carcinogenesis of colorectal cancer (CRC) involves many different molecules and multiple pathways, and the specific mechanism has not been elucidated until now. Existing studies on the proteomic signature profiles of CRC are relatively limited. Therefore, we herein aimed to provide a more comprehensive proteomic signature profile and discover new prognostic markers and therapeutic targets by performing proteomic analysis of CRC and paired normal tissues.

Aim

To investigate the proteomic signature and identify novel protein prognostic biomarkers of CRC.

Methods

Cancer tissues and paired normal tissues were collected from 48 patients who underwent surgical removal at the China-Japan Friendship Hospital from January 2020 to June 2021. Data independent acqu

SUBMITTER: Wang QQ 

PROVIDER: S-EPMC9372836 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature