Plasma protein profiling reveals dynamic immunomodulatory changes in multiple sclerosis patients during pregnancy.

ABSTRACT: Multiple sclerosis (MS) is a chronic autoimmune neuroinflammatory and neurodegenerative disorder of the central nervous system. Pregnancy represents a natural modulation of the disease course, where the relapse rate decreases, especially in the 3^rd trimester, followed by a transient exacerbation after delivery. Although the exact mechanisms behind the pregnancy-induced modulation are yet to be deciphered, it is likely that the immune tolerance established during pregnancy is involved. In this study, we used the highly sensitive and specific proximity extension assay technology to perform protein profiling analysis of 92 inflammation-related proteins in MS patients (n=15) and healthy controls (n=10), longitudinally sampled before, during, and after pregnancy. Differential express

SUBMITTER: Papapavlou Lingehed G 

PROVIDER: S-EPMC9373039 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature