[Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis].

ABSTRACT:

Background

Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5-Hydroxytryptamine3 (5-HT3) receptor antagonists and Neurokinin-1 (NK-1) receptor antagonists, have been used to treat PONV.

Objectives

To compare the antiemetic effect of NK-1 receptor antagonists, including fosaprepitant.

Data sources

Online databases (PubMed, MEDLINE, Scopus, The Cochrane Library databases) were used.

Study eligibility criteria, participants, and interventions

Randomized Controlled Trials (RCTs) performed in patients over 18 years with ASA-PS of I-III, aimed to assess the efficacy of antiemetics including NK-1 receptor antagonists and 5-HT3 receptor antagonists, and compared the incidence of PONV were i

SUBMITTER: Murakami C 

PROVIDER: S-EPMC9373091 | biostudies-literature | 2020 Sep - Oct

REPOSITORIES: biostudies-literature