Comprehensive Analysis of the Significance of Ferroptosis-Related Genes in the Prognosis and Immunotherapy of Oral Squamous Cell Carcinoma.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is a life-threatening disease, associated with poor prognosis and the absence of specific biomarkers. Studies have shown that the ferroptosis-related genes (FRGs) can be used as tumor prognostic markers. However, FRGs' prognostic value in OSCC needs further exploration. In our study, gene expression profile and clinical data of OSCC patients were collected from a public domain. We performed univariate and multivariate Cox regression analyses to construct a multigene signature. The Kaplan-Meier and receiver operating characteristic (ROC) methods were used to test the effectiveness of the signature, followed by the expression analysis of human leukocyte antigen (HLA) and immune checkpoints. The Cox regression analysis identified 4 hubs from 103 FRGs expres

SUBMITTER: Yin J 

PROVIDER: S-EPMC9373167 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature