Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently.

ABSTRACT:

Background

Factorial designs and multi-arm multi-stage (MAMS) platform designs have many advantages, but the practical advantages and disadvantages of combining the two designs have not been explored.

Methods

We propose practical methods for a combined design within the platform trial paradigm where some interventions are not expected to interact and could be given together.

Results

We describe the combined design and suggest diagrams that can be used to represent it. Many properties are common both to standard factorial designs, including the need to consider interactions between interventions and the impact of intervention efficacy on power of other comparisons, and to standard multi-arm multi-stage designs, including the need to pre-specify procedures for starting

SUBMITTER: White IR 

PROVIDER: S-EPMC9373200 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature