The effect of propofol-sufentanil intravenous anesthesia on systemic and cerebral circulation, cerebral autoregulation and CO₂ reactivity: a case series.

ABSTRACT:

Background and objectives

The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO₂-reactivity during propofol anesthesia.

Methods

27 patients undergoing general anesthesia were enrolled. Anesthesia was maintained using the Target-Controlled Infusion (TCI) method according to the Schnider model, effect site propofol concentration of 4 μg.mL^-1. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35, and 30 mmHg EtCO₂ for 5 minutes, respectively. At the end of each period, transcranial Doppler and hemodynamic parameters using applanation tonometry were recorded.

Results

Systemic mean arterial pressure significantly decreased during anesthetic inductio

SUBMITTER: Juhasz M 

PROVIDER: S-EPMC9373201 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature