[Comparison of two doses of intra-articular tranexamic acid on postoperative bleeding in total knee arthroplasty: a randomized clinical trial].

ABSTRACT:

Introduction

Tranexamic Acid (TXA), an antifibrinolytic that inhibits the fibrinolytic activity of plasmin is used to decrease perioperative blood loss and transfusion requirements in orthopedic surgery. The aim of our study was to compare postoperative bleeding in two intra-articular doses (1g and 2g) of tranexamic acid in adult patients undergoing unilateral total knee replacement.

Method

We conducted a single-operator, randomized, and controlled, double-blind study in two groups. The G1 group received 1g of intra-articular TXA and the G2 group 2g of intra-articular TXA. Both groups received 15mg.kg^-1 IV before the surgical incision (TXA induction dose) and then 10mg.kg^-1, orally, 6 and 12hours after the induction dose of TXA. The primary endpoint was

SUBMITTER: Souza Neto EP 

PROVIDER: S-EPMC9373250 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature