Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity.

ABSTRACT:

Background

For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In theory, these methods would be cheap to produce, broadly applicable in a wide array of cancer types, and could synergize with other cancer treatment strategies. We aimed to assess the efficacy of combining microbial-based therapy using Salmonella SL7207 with interleukin-2 (IL-2), a potent immunostimulatory agent, in the treatment of murine colon carcinoma.

Methods

Female BALB/c mice were implanted subcutaneously with CT26 tumors, a model of colon carcinoma. Mice bearing tumors were selected and administered Albumin-IL-2 (Alb-IL2), a fusion protein, for further analysis of anticancer effect.

Results

We demonstrated that Salmonella SL7207, a

SUBMITTER: Kung YJ 

PROVIDER: S-EPMC9373295 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature