Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level.

ABSTRACT:

Background

Horizontal gene transfer (HGT) plays a critical role in the spread of antibiotic resistance and the evolutionary shaping of bacterial communities. Conjugation is the most well characterized pathway for the spread of antibiotic resistance, compared to transformation and transduction. While antibiotics have been found to induce HGT, it remains unknown whether non-antibiotic pharmaceuticals can facilitate conjugation at a microbial community-wide level.

Results

In this study, we demonstrate that several commonly consumed non-antibiotic pharmaceuticals (including carbamazepine, ibuprofen, naproxen and propranolol), at environmentally relevant concentrations (0.5 mg/L), can promote the conjugative transfer of IncP1-α plasmid-borne antibiotic resistance across entire mi

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9373378 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature