Effects of lidocaine and esmolol on hemodynamic response to tracheal intubation: a randomized clinical trial.

ABSTRACT:

Introduction and objectives

Although lidocaine is widely used to prevent cardiovascular changes resulting from laryngoscopy and orotracheal intubation, it is still unclear whether there are more efficacious drugs. This study aimed to compare the beta-blocker esmolol with lidocaine regarding the effects on hemodynamic response after orotracheal intubation.

Methods

The study has a prospective, randomized, double-blind, superiority design, and assessed 69 participants between 18 and 70 years of age, ASA I-II, scheduled for elective or emergency surgery under general anesthesia with orotracheal intubation. Participants were randomly allocated to receive 1.5 mg.kg^-1 esmolol bolus followed by 0.1 mg.kg^-1.min^-1 esmolol infusion (n = 34) or 1.5 mg.kg

SUBMITTER: Mendonca FT 

PROVIDER: S-EPMC9373404 | biostudies-literature | 2022 Jan-Feb

REPOSITORIES: biostudies-literature