[Influence of methylprednisolone on the reversal time of sugammadex: a randomized clinical trial].

ABSTRACT:

Background and objectives

Sugammadex is a modified gamma-cyclodextrin that reverses the effects of aminosteroidal neuromuscular blocking agents. Likewise, some steroid molecules, such as toremifene, fusidic acid, and flucloxacillin, can also be encapsulated by sugammadex. Methylprednisolone, which is a synthetic steroid used commonly for airway oedema prophylaxis, can also be encapsulated by sugammadex. The objective of this study was to compare the recovery times of sugammadex for reversing rocuronium-induced moderate neuromuscular blockade in those who received intraoperative 1 mg.kg^-1 methylprednisolone or saline.

Method

This single-centered, randomized, controlled, prospective study included 162 adult patients undergoing elective ear-nose-throat procedures (ag

SUBMITTER: Kocaoglu MH 

PROVIDER: S-EPMC9373425 | biostudies-literature | 2020 Mar - Apr

REPOSITORIES: biostudies-literature