Molecular evolutionary process of advanced gastric cancer during sequential chemotherapy detected by circulating tumor DNA.

ABSTRACT:

Background

Efficacy of conventional sequential chemotherapy paradigm for advanced gastric cancer (AGC) patients has largely plateaued. Dynamic molecular changes during and after sequential chemotherapy have not been fully delineated. We aimed to profile the molecular evolutionary process of AGC patients during sequential chemotherapy by next generation sequencing (NGS) of plasma circulating tumor DNA (ctDNA).

Methods

A total of 30 chemo-naïve patients who were diagnosed with unresectable advanced or metastatic stomach adenocarcinoma were enrolled. All patients received sequential chemotherapy regimens following the clinical guideline. One hundred and eight serial peripheral blood samples were collected at baseline, radiographical assessment and disease progression. Plasma ct

SUBMITTER: Xi W 

PROVIDER: S-EPMC9373478 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature