Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial.

ABSTRACT:

Background

Cardiopulmonary bypass (CPB) causes systemic oxidative stress response and endothelial damage in systemic organs. We investigated the effects of positive end-expiratory pressure (PEEP) and mechanical ventilation (MV) applications on oxidative stress in CPB.

Methods

Seventy-one patients were recruited and 60 completed the study. Randomized groups: MV off (Group 1); MV on, tidal volume (TV) at 3-4 mL.kg^-1 (Group 2); MV on, TV at 3-4 mL.kg^-1, PEEP at 5 cmH2O (Group 3), n = 20 in each group. As oxidative stress markers, we used glutathione peroxidase (GPx), total antioxidant status (TAS), total oxidant status (TOS), total and native thiol (TT, NT), malondialdehyde (MDA), and catalase. We also investigated the correlation between oxidative stress

SUBMITTER: Orak Y 

PROVIDER: S-EPMC9373507 | biostudies-literature | 2022 Jan-Feb

REPOSITORIES: biostudies-literature