Characterization of the major control region of Vibrio cholerae bacteriophage K139: immunity, exclusion, and integration.

ABSTRACT: The temperate bacteriophage K139 is highly associated with pathogenic O1 Vibrio cholerae strains. The nucleotide sequence of the major control region of K139 was determined. The sequences of four (cox, cII, cI, and int) of the six deduced open reading frames and their gene order indicated that K139 is related to the P2 bacteriophage family. Two genes of the lysogenic transcript from the mapped promoter PL encode homologs to the proteins CI and Int, with deduced functions in prophage formation and maintenance. Between the cI and int genes, two additional genes were identified: orf2, which has no significant similarity to any other gene, and the formerly characterized gene glo. Further analysis revealed that Orf2 is involved in preventing superinfection. In a previous report, we described th

SUBMITTER: Nesper J 

PROVIDER: S-EPMC93736 | biostudies-literature | 1999 May

REPOSITORIES: biostudies-literature