The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.

ABSTRACT:

Objective

A missense variant, rs373863828, in CREBRF is associated with obesity in Polynesians. We investigate whether rs373863828 and other factors are associated with body mass index (BMI) rate-of-change between 2010 and 2017-19 in Samoans.

Methods

We used sex-stratified models to test whether BMI rate-of-change was associated with rs373863828, baseline BMI, age, residence, physical activity, and household asset score in a cohort study of 480 Samoan adults measured in both 2010 (mean age 43.8 years) and 2017-19.

Results

Mean BMI increased from 32.1 to 33.5 kg/m² in males (n = 220, p = 1.3 ×10^-8) and from 35.9 to 37.8 kg/m² in females (n = 260, p = 1.2 ×10^-13). In females, the A allele was associated with a higher rate-of-c

SUBMITTER: Fu H 

PROVIDER: S-EPMC9373717 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature