Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice.

ABSTRACT:

Background

The effect of oral microbiota on the intestinal microbiota has garnered growing attention as a mechanism linking periodontal diseases to systemic diseases. However, the salivary microbiota is diverse and comprises numerous bacteria with a largely similar composition in healthy individuals and periodontitis patients.

Aim

We explored how health-associated and periodontitis-associated salivary microbiota differently colonized the intestine and their subsequent systemic effects.

Methods

The salivary microbiota was collected from a healthy individual and a periodontitis patient and gavaged into C57BL/6NJcl[GF] mice. Gut microbial communities, hepatic gene expression profiles, and serum metabolites were analyzed.

Results

The gut microbial composition was s

SUBMITTER: Yamazaki K 

PROVIDER: S-EPMC9373767 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature