Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.

ABSTRACT: Rationale: Immunosuppression in the tumor microenvironment (TME) is key to the pathogenesis of solid tumors. Tumor cell-intrinsic autophagy is critical for sustaining both tumor cell metabolism and survival. However, the role of autophagy in the host immune system that allows cancer cells to escape immune destruction remains poorly understood. Here, we determined if attenuated host autophagy is sufficient to induce tumor rejection through reinforced adaptive immunity. Furthermore, we determined whether dietary glutamine supplementation, mimicking attenuated host autophagy, is capable of promoting antitumor immunity. Methods: A syngeneic orthotopic tumor model in Atg5^+/+ and Atg5^flox/flox mice was established to determine the impact of host

SUBMITTER: Cao S 

PROVIDER: S-EPMC9373812 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature