Age-Dependent Behavioral and Metabolic Assessment of App ^{NL-G-F/NL-G-F} Knock-in (KI) Mice.

ABSTRACT: Mitochondria play a crucial role in Alzheimer's disease (AD) onset and progression. Traditional transgenic AD mouse models which were widely used in the past decades share a common limitation: The overexpression of APP and overproduction of amyloid-beta (Aβ) are accompanied by other APP peptide fragments, which could introduce artificial and non-clinically relevant phenotypes. Here, we performed an in-depth and time-resolved behavioral and metabolic characterization of a clinically relevant AD mouse model engineered to express normal physiological levels of APP harboring humanized Swedish (K670N/M671L), Beyreuther/Iberian (I716F), and Arctic (E693G) mutations (App ^{NL-G-F/NL-G-F} ), termed APP knock-in (APPKI) mice. Our result showe

SUBMITTER: Wang S 

PROVIDER: S-EPMC9373872 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature