ACTH-independent Cushing's syndrome due to ectopic endocrinologically functional adrenal tissue caused by a GNAS heterozygous mutation: a rare case of McCune-Albright syndrome accompanied by central amenorrhea and hypothyroidism: a case report and literature review.

ABSTRACT: In a small number of cases, the development of ectopic residual adrenal lesions during embryogenesis causing Cushing's syndrome due to the production of excess cortisol has been reported. A 29-year-old woman was admitted to our hospital for fatigue and recent amenorrhea. Her plasma ACTH was <1.5 pg/mL, and her serum cortisol was 21.4 pg/mL after the 8 mg dexamethasone suppression test, revealing the presence of ACTH-independent Cushing's syndrome; however, her bilateral adrenal glands were atrophied. Abdominal CT revealed a 40-mm round tumor on the right renal hilum and remarkably accumulated ¹³¹I-labelled adosterol. CT and bone scintigraphy showed that ^99mTc-methylene diphosphonate had accumulated in her dissymmetric skull at the right-frontoparietal region. The tumo

SUBMITTER: Takedani K 

PROVIDER: S-EPMC9373900 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature