Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.

ABSTRACT: Metabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, as is MetS. As a genetically complex disease, genetic risk factors for MetS are numerous, but not very powerful individually, often requiring specific environmental stressors for the disease to manifest. When taken together, all sequence variants t

SUBMITTER: Clark KC 

PROVIDER: S-EPMC9373910 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature