Alcohol-related hepatocellular carcinoma is a heterogenous condition: Lessons from a latent class analysis.

ABSTRACT:

Background

Alcohol-associated hepatocellular carcinoma (AL-HCC) poor prognosis has been attributed to diagnosis at a later stage. However, host factors and specific health trajectories have been associated with severe outcomes in alcohol-related liver disease. We hypothesize AL-HCC is not a homogeneous condition but encompasses subgroups yielding different outcomes.

Aims

Our aim was to provide a first attempt at a clinical phenotyping of AL-HCC.

Methods

We analysed data for the calendar years 2007-2013 from the French nationwide administrative hospital database. We selected patients with AL-HCC only. Clustering of AL-HCC phenotypes was performed by latent class analysis (LCA).

Results

The study included 11 363 patients with AL-HCC, mainly male (89.6%), median a

SUBMITTER: Costentin CE 

PROVIDER: S-EPMC9373918 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature