Effects of Vitamin D on Physical Function: Results From the STURDY Trial.

ABSTRACT:

Background

Studies of the relationship between vitamin D and physical functioning have had inconsistent results.

Methods

Physical functioning measures were collected for up to 2 years during a 2-stage, Bayesian, response-adaptive, randomized trial of 4 doses of vitamin D3 supplementation (200 [control], 1 000, 2 000, and 4 000 IU/day) to prevent falls. Two community-based research units enrolled adults aged ≥70 years, with elevated fall risk and serum 25-hydroxyvitamin D level of 10-29 ng/mL. The Pooled Higher Doses (PHD) group (≥1 000 IU/day, n = 349) was compared to the control group (n = 339) on changes in Short Physical Performance Battery (SPPB) score and its component tests, Timed Up-and-Go (TUG) test, 6-minute walk distance, and grip strength.

Results

The trial

SUBMITTER: Guralnik JM 

PROVIDER: S-EPMC9373949 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature