Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3.

ABSTRACT: Several chemical compounds including natural products have been suggested as being effective against age-related diseases or as beneficial for a healthy life. On the other hand, forkhead box O (FOXO) proteins are emerging as key cellular components associated with extreme human longevity. FOXO proteins are mainly regulated by posttranslational modifications and as these modifications are reversible, activation and inactivation of FOXO are attainable through pharmacological treatment. Here, we questioned whether a panel of compounds with known health-beneficial properties has the capacity to induce the activity of FOXO factors. We show that resveratrol, a phytoalexin present in grapes and other food products, the amide alkaloid piperlongumine found in the fruit of the long pepper, and the p

SUBMITTER: Jimenez L 

PROVIDER: S-EPMC9373959 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature